Phase I Trial and Pharmacokinetic Study of Sorafenib in Children With Neurofibromatosis Type I and Plexiform Neurofibromas

BACKGROUND. Sorafenib targets multiple pathways thought to be crucial in growth of plexiform neurofibroma (PN) in children with neurofibromatosis type 1 (NF1). Sorafenib has been tolerated with manageable toxicities in adults and children with refractory cancer. We conducted a separate study in this...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Kim, AeRang, Dombi, Eva, Tepas, Kathleen, Fox, Elizabeth, Martin, Staci, Wolters, Pamela, Balis, Frank M., Jayaprakash, Nalini, Turkbey, Baris, Muradyan, Naira, Choyke, Peter L., Reddy, Alyssa, Korf, Bruce, Widemann, Brigitte C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309697/
https://ncbi.nlm.nih.gov/pubmed/22961690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24281
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