The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through a unique mechanism to disrupt Ras-ERK signaling

The Ras-ERK (extracellular signal–regulated kinase) pathway is critical for controlling cell proliferation, and its aberrant activation drives the growth of various cancers. Because many pathogens produce toxins that inhibit Ras activity, efforts to develop effective Ras inhibitors for treating canc...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Biancucci, Marco, Minasov, George, Banerjee, Avik, Herrera, Alfa, Woida, Patrick J., Kieffer, Matthew B., Bindu, Lakshman, Abreu-Blanco, Maria, Anderson, Wayne F., Gaponenko, Vadim, Stephen, Andrew G., Holderfield, Matthew, Satchell, Karla J. F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309442/
https://ncbi.nlm.nih.gov/pubmed/30279169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat8335
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