Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018

Clostridioides difficile toxin A (TcdA) and Toxin B (TcdB) trigger inflammasome activation with caspase-1 activation in cultured cells, which in turn induce the release of IL-6, IFN-γ, and IL-8. Release of these proinflammatory responses is positively regulated by Ras-GTPases, which leads to the hyp...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Main Authors: Genth, Harald, Junemann, Johannes, Lämmerhirt, Chantal M., Lücke, Arlen-Celina, Schelle, Ilona, Just, Ingo, Gerhard, Ralf, Pich, Andreas
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308379/
https://ncbi.nlm.nih.gov/pubmed/30622517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.03078
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