Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

Glioblastoma is highly enriched with macrophages, and osteopontin (OPN) expression levels correlate with glioma grade and the degree of macrophage infiltration; thus, we studied whether OPN plays a crucial role in immune modulation. Quantitative PCR, immunoblotting, and ELISA were used to determine...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wei, Jun, Marisetty, Anantha, Schrand, Brett, Gabrusiewicz, Konrad, Hashimoto, Yuuri, Ott, Martina, Grami, Zacharia, Kong, Ling-Yuan, Ling, Xiaoyang, Caruso, Hillary, Zhou, Shouhao, Wang, Y. Alan, Fuller, Gregory N., Huse, Jason, Gilboa, Eli, Kang, Nannan, Huang, Xingxu, Verhaak, Roel, Li, Shulin, Heimberger, Amy B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307970/
https://ncbi.nlm.nih.gov/pubmed/30307407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121266
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