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High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors
Tumors responding to immune checkpoint inhibitors (ICIs) have a higher level of immune infiltrates and/or an Interferon (IFN) signature indicative of a T-cell-inflamed phenotype. Melanoma and lung cancer demonstrate high response rates to ICIs and are commonly referred to as “hot tumors”. These are...
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| Publicado no: | J Immunother Cancer |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6307306/ https://ncbi.nlm.nih.gov/pubmed/30587233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0479-7 |
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