Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway

BACKGROUND: Hypoxia commonly occurs in solid tumors. The hypoxia in the center of solid tumors considerably decreases the chemosensitivity of tumor cells and induces epithelial–mesenchymal transition (EMT) as well as drug resistance of antitumor drugs. METHODS: Here, the effects of salidroside (Sal)...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Qin, Yuan, Liu, Hui-juan, Li, Meng, Zhai, Deng-hui, Tang, Yuan-hao, Yang, Lan, Qiao, Kai-liang, Yang, Jia-huan, Zhong, Wei-long, Zhang, Qiang, Liu, Yan-rong, Yang, Guang, Sun, Tao, Yang, Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306459/
https://ncbi.nlm.nih.gov/pubmed/30396856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.10.069
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