Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium

BACKGROUND: We recently reported that myeloid sirtuin 6 (Sirt6) is a critical determinant of phenotypic switching and the migratory responses of macrophages. Given the prominent role of macrophages in the pathogenesis of rheumatoid arthritis (RA), we tested whether myeloid Sirt6 deficiency affects t...

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Bibliografiske detaljer
Udgivet i:EBioMedicine
Main Authors: Woo, Seong Ji, Noh, Hae Sook, Lee, Na Young, Cheon, Yun-Hong, Yi, Sang Mi, Jeon, Hyun Min, Bae, Eun Ju, Lee, Sang-Il, Park, Byung-Hyun
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306347/
https://ncbi.nlm.nih.gov/pubmed/30429089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.005
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