Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium

BACKGROUND: We recently reported that myeloid sirtuin 6 (Sirt6) is a critical determinant of phenotypic switching and the migratory responses of macrophages. Given the prominent role of macrophages in the pathogenesis of rheumatoid arthritis (RA), we tested whether myeloid Sirt6 deficiency affects t...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Woo, Seong Ji, Noh, Hae Sook, Lee, Na Young, Cheon, Yun-Hong, Yi, Sang Mi, Jeon, Hyun Min, Bae, Eun Ju, Lee, Sang-Il, Park, Byung-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306347/
https://ncbi.nlm.nih.gov/pubmed/30429089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.005
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