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Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors. Here, we set up a scalable process for AAV...

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Bibliografski detalji
Izdano u:Mol Ther Methods Clin Dev
Glavni autori: Blessing, Daniel, Vachey, Gabriel, Pythoud, Catherine, Rey, Maria, Padrun, Vivianne, Wurm, Florian M., Schneider, Bernard L., Déglon, Nicole
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305802/
https://ncbi.nlm.nih.gov/pubmed/30591923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.11.004
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