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Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors. Here, we set up a scalable process for AAV...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Blessing, Daniel, Vachey, Gabriel, Pythoud, Catherine, Rey, Maria, Padrun, Vivianne, Wurm, Florian M., Schneider, Bernard L., Déglon, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305802/
https://ncbi.nlm.nih.gov/pubmed/30591923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2018.11.004
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