CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II

Under non-inflammatory conditions HLA class II is predominantly expressed on hematopoietic cells. Therefore, donor CD4 T-cells after allogeneic stem cell transplantation (alloSCT) may mediate graft-vs.-leukemia reactivity without graft-vs.-host disease (GVHD). We analyzed immune responses in four pa...

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Bibliographic Details
Published in:Front Immunol
Main Authors: van Balen, Peter, van Bergen, Cornelis A. M., van Luxemburg-Heijs, Simone A. P., de Klerk, Wendy, van Egmond, Esther H. M., Veld, Sabrina A. J., Halkes, Constantijn J. M., Zwaginga, Jaap-Jan, Griffioen, Marieke, Jedema, Inge, Falkenburg, J. H. Frederik
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305328/
https://ncbi.nlm.nih.gov/pubmed/30619360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03016
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