Probing the mechanism of inhibition of amyloid-β(1–42)–induced neurotoxicity by the chaperonin GroEL

The human chaperonin Hsp60 is thought to play a role in the progression of Alzheimer’s disease by mitigating against intracellular β-amyloid stress. Here, we show that the bacterial homolog GroEL (51% sequence identity) reduces the neurotoxic effects of amyloid-β(1–42) (Aβ42) on human neural stem ce...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wälti, Marielle A., Steiner, Joseph, Meng, Fanjie, Chung, Hoi Sung, Louis, John M., Ghirlando, Rodolfo, Tugarinov, Vitali, Nath, Avindra, Clore, G. Marius
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304969/
https://ncbi.nlm.nih.gov/pubmed/30509980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817477115
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