Chaperonin GroEL accelerates protofibril formation and decorates fibrils of the Het-s prion protein

We have studied the interaction of the prototypical chaperonin GroEL with the prion domain of the Het-s protein using solution and solid-state NMR, electron and atomic force microscopies, and EPR. While GroEL accelerates Het-s protofibril formation by several orders of magnitude, the rate of appeara...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Wälti, Marielle A., Schmidt, Thomas, Murray, Dylan T., Wang, Huaibin, Hinshaw, Jenny E., Clore, G. Marius
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576843/
https://ncbi.nlm.nih.gov/pubmed/28784759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711645114
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