Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB

Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypom...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Yan, Run, Zhang, Jie, Park, Hye-Jin, Park, Eun S., Oh, Stephanie, Zheng, Haiyan, Junn, Eunsung, Voronkov, Michael, Stock, Jeffry B., Mouradian, M. Maral
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304960/
https://ncbi.nlm.nih.gov/pubmed/30509990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1813365115
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