Knockout of both miR-15/16 loci induces acute myeloid leukemia

MicroRNAs (miRNAs) have been extensively reported to be associated with hematological malignancies. The loss of miR-15a/16–1 at chromosome 13q14 is a hallmark of most of human chronic lymphocytic leukemia (CLL). Deletion of murine miR-15a/16–1 and miR-15b/16–2 has been demonstrated to promote B cell...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lovat, Francesca, Fassan, Matteo, Sacchi, Diana, Ranganathan, Parvathi, Palamarchuk, Alexey, Bill, Marius, Karunasiri, Malith, Gasparini, Pierluigi, Nigita, Giovanni, Distefano, Rosario, Veneziano, Dario, Dorrance, Adrienne M., Garzon, Ramiro, Croce, Carlo M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304943/
https://ncbi.nlm.nih.gov/pubmed/30478046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814980115
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