Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

TNF is a multifunctional cytokine involved in autoimmune disease pathogenesis that exerts its effects through two distinct TNF receptors, TNFR1 and TNFR2. While TNF- and TNFR1-deficient (but not TNFR2-deficient) mice show very similar phenotypes, the significance of TNFR2 signaling in health and dis...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Atretkhany, Kamar-Sulu N., Mufazalov, Ilgiz A., Dunst, Josefine, Kuchmiy, Anna, Gogoleva, Violetta S., Andruszewski, David, Drutskaya, Marina S., Faustman, Denise L., Schwabenland, Marius, Prinz, Marco, Kruglov, Andrey A., Waisman, Ari, Nedospasov, Sergei A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6304938/
https://ncbi.nlm.nih.gov/pubmed/30498033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807499115
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