VHH-Based Bispecific Antibodies Targeting Cytokine Production

Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their systemic neutralization carries the potential for...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Nosenko, Maxim A., Atretkhany, Kamar-Sulu N., Mokhonov, Vladislav V., Efimov, Grigory A., Kruglov, Andrey A., Tillib, Sergei V., Drutskaya, Marina S., Nedospasov, Sergei A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585155/
https://ncbi.nlm.nih.gov/pubmed/28919896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01073
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