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Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK
BRAF is a cytoplasmic protein kinase, which activates the MEK-ERK signalling pathway. Deregulation of the pathway is associated with the presence of BRAF mutations in human cancer, the most common being (V600E)BRAF, although structural rearrangements, which remove N-terminal regulatory sequences, ha...
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| Wydane w: | Heliyon |
|---|---|
| Główni autorzy: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Elsevier
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6304467/ https://ncbi.nlm.nih.gov/pubmed/30603699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2018.e01065 |
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