Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene

BACKGROUND. Matrix metalloprotease 9 (MMP-9) is associated with inflammation and lung remodeling in chronic obstructive pulmonary disease (COPD). We hypothesized that elevated circulating MMP-9 represents a potentially novel biomarker that identifies a subset of individuals with COPD with an inflamm...

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Publicado no:JCI Insight
Main Authors: Wells, J. Michael, Parker, Margaret M., Oster, Robert A., Bowler, Russ P., Dransfield, Mark T., Bhatt, Surya P., Cho, Michael H., Kim, Victor, Curtis, Jeffrey L., Martinez, Fernando J., Paine, Robert, O’Neal, Wanda, Labaki, Wassim W., Kaner, Robert J., Barjaktarevic, Igor, Han, MeiLan K., Silverman, Edwin K., Crapo, James D., Barr, R. Graham, Woodruff, Prescott, Castaldi, Peter J., Gaggar, Amit, Investigators, the SPIROMICS and COPDGene
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302944/
https://ncbi.nlm.nih.gov/pubmed/30429371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.123614
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