Complement serves as a switch between CD4(+) T cell–independent and –dependent RBC antibody responses

RBC alloimmunization represents a significant immunological challenge for patients requiring lifelong transfusion support. The majority of clinically relevant non-ABO(H) blood group antigens have been thought to drive antibody formation through T cell–dependent immune pathways. Thus, we initially so...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Mener, Amanda, Patel, Seema R., Arthur, Connie M., Chonat, Satheesh, Wieland, Andreas, Santhanakrishnan, Manjula, Liu, Jingchun, Maier, Cheryl L., Jajosky, Ryan P., Girard-Pierce, Kathryn, Bennett, Ashley, Zerra, Patricia E., Smith, Nicole H., Hendrickson, Jeanne E., Stowell, Sean R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302935/
https://ncbi.nlm.nih.gov/pubmed/30429364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121631
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