Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming

Mitochondria are key players in the regulation of T cell biology by dynamically responding to cell needs, but how these dynamics integrate in T cells is still poorly understood. We show here that the mitochondrial pro-fission protein Drp1 fosters migration and expansion of developing thymocytes both...

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Publicado en:Cell Rep
Main Authors: Simula, Luca, Pacella, Ilenia, Colamatteo, Alessandra, Procaccini, Claudio, Cancila, Valeria, Bordi, Matteo, Tregnago, Claudia, Corrado, Mauro, Pigazzi, Martina, Barnaba, Vincenzo, Tripodo, Claudio, Matarese, Giuseppe, Piconese, Silvia, Campello, Silvia
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302735/
https://ncbi.nlm.nih.gov/pubmed/30540939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.018
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