GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner

Glucagon-like peptide 1 (GLP-1) is known to suppress glucagon secretion, but the mechanism by which GLP-1 exerts this effect is unclear. In this study, we demonstrated GLP-1 receptor (GLP-1R) expression in α-cells using both antibody-dependent and antibody-independent strategies. A novel α-cell–spec...

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Bibliografiske detaljer
Udgivet i:Diabetes
Main Authors: Zhang, Yanqing, Parajuli, Keshab R., Fava, Genevieve E., Gupta, Rajesh, Xu, Weiwei, Nguyen, Lauren U., Zakaria, Anadil F., Fonseca, Vivian A., Wang, Hongjun, Mauvais-Jarvis, Franck, Sloop, Kyle W., Wu, Hongju
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2019
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302540/
https://ncbi.nlm.nih.gov/pubmed/30389749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0317
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