PAX4 Gene Transfer Induces α-to-β Cell Phenotypic Conversion and Confers Therapeutic Benefits for Diabetes Treatment

The transcription factor Pax4 plays a critical role in the determination of α- versus β-cell lineage during endocrine pancreas development. In this study, we explored whether Pax4 gene transfer into α-cells could convert them into functional β-cells and thus provide therapeutic benefits for insulin-...

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Udgivet i:Mol Ther
Main Authors: Zhang, Yanqing, Fava, Genevieve E, Wang, Hongjun, Mauvais-Jarvis, Franck, Fonseca, Vivian A, Wu, Hongju
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817809/
https://ncbi.nlm.nih.gov/pubmed/26435408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.181
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