Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA–mDia2 signaling and filopodium formation

Chloride intracellular channel 4 (CLIC4) is a cytosolic protein implicated in diverse actin-based processes, including integrin trafficking, cell adhesion, and tubulogenesis. CLIC4 is rapidly recruited to the plasma membrane by RhoA-activating agonists and then partly colocalizes with β1 integrins....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Argenzio, Elisabetta, Klarenbeek, Jeffrey, Kedziora, Katarzyna M., Nahidiazar, Leila, Isogai, Tadamoto, Perrakis, Anastassis, Jalink, Kees, Moolenaar, Wouter H., Innocenti, Metello
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302171/
https://ncbi.nlm.nih.gov/pubmed/30381396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002779
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