Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response

The human IL22RA2 gene co-produces three protein isoforms in dendritic cells [IL-22 binding protein isoform-1 (IL-22BPi1), IL-22BPi2, and IL-22BPi3]. Two of these, IL-22BPi2 and IL-22BPi3, are capable of neutralizing the biological activity of IL-22. The function of IL-22BPi1, which differs from IL-...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Gómez-Fernández, Paloma, Urtasun, Andoni, Paton, Adrienne W., Paton, James C., Borrego, Francisco, Dersh, Devin, Argon, Yair, Alloza, Iraide, Vandenbroeck, Koen
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302113/
https://ncbi.nlm.nih.gov/pubmed/30619294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02934
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