T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice

T-type calcium channels in the brain mediate the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel therapeutic candidate, SAK3 (ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopentane-1,3'-imidazo[1,2-a] pyridine]-2-ene-3-carboxylate), for...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Shuo, Yabuki, Yasushi, Matsuo, Kazuya, Xu, Jing, Izumi, Hisanao, Sakimura, Kenji, Saito, Takashi, Saido, Takaomi C., Fukunaga, Kohji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301769/
https://ncbi.nlm.nih.gov/pubmed/30571684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206986
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