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T-Type Ca(2+) Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model

Lewy bodies are pathological characteristics of Lewy body dementia (LBD) and are composed of α-synuclein (α-Syn), which is mostly degraded via the ubiquitin–proteasome system. More importantly, 26S proteasomal activity decreases in the brain of LBD patients. We recently introduced a T-type calcium c...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Xu, Jing, Kawahata, Ichiro, Izumi, Hisanao, Fukunaga, Kohji
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228122/
https://ncbi.nlm.nih.gov/pubmed/34201181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126185
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