Neurofibromin haploinsufficiency results in altered spermatogenesis in a mouse model of neurofibromatosis type 1

The fertility of men with neurofibromatosis 1 (NF1) is reduced. Despite this observation, gonadal function has not been examined in patients with NF1. In order to assess the role of reduced neurofibromin in the testes, we examined testicular morphology and function in an Nf1(+/-) mouse model. We fou...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Chohan, Harleen, Esfandiarei, Mitra, Arman, Darian, Van Raamsdonk, Catherine D., van Breemen, Cornelis, Friedman, Jan M., Jett, Kimberly A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301684/
https://ncbi.nlm.nih.gov/pubmed/30571760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208835
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