Exploring the effectiveness of novel benzimidazoles as CB2 ligands: synthesis, biological evaluation, molecular docking studies and ADMET prediction

Herein we continued our previous work on the development of CB2 ligands, reporting the design and synthesis of a series of benzimidazole-containing derivatives that were explored as selective CB2 ligands with binding affinity towards both CB1 and CB2 receptors. Seven out of eighteen compounds exhibi...

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Vydáno v:Medchemcomm
Hlavní autoři: Tonelli, Michele, Cichero, Elena, Mahmoud, Alì Mokhtar, Rabbito, Alessandro, Tasso, Bruno, Fossa, Paola, Ligresti, Alessia
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2018
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301267/
https://ncbi.nlm.nih.gov/pubmed/30647880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00461g
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