Pharmacokinetic interaction between mitotane and etoposide in adrenal carcinoma: a pilot study

BACKGROUND: The combination of mitotane and platinum-etoposide chemotherapy is a front-line treatment in metastatic adrenocortical carcinoma (ACC), although this regimen shows limited efficacy. Pharmacokinetic drug–drug interaction between mitotane, a strong CYP3A4 inducer, and etoposide, which is a...

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Detalhes bibliográficos
Publicado no:Endocr Connect
Main Authors: Jouinot, Anne, Royer, Bernard, Chatelut, Etienne, Moeung, Sotheara, Assié, Guillaume, Thomas-Schoemann, Audrey, Bertherat, Jérôme, Goldwasser, François, Blanchet, Benoit
Formato: Artigo
Idioma:Inglês
Publicado em: Bioscientifica Ltd 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301193/
https://ncbi.nlm.nih.gov/pubmed/30533000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-18-0428
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