Microbiota-induced TNF-like ligand 1A drives group 3 innate lymphoid cell-mediated barrier protection and intestinal T cell activation during colitis

Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Castellanos, Jim G., Woo, Viola, Viladomiu, Monica, Putzel, Gregory, Lima, Svetlana, Diehl, Gretchen E., Marderstein, Andrew, Gandara, Jorge, Perez, Alexendar R., Withers, David R., Targan, Stephan R., Shih, David Q., Scherl, Ellen J., Longman, Randy S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301104/
https://ncbi.nlm.nih.gov/pubmed/30552020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.10.014
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