Pharmacokinetics of temozolomide administered in combination with O(6)-benzylguanine in children and adolescents with refractory solid tumors

PURPOSE: Temozolomide pharmacokinetics were evaluated in children receiving concurrent O(6)-benzylguanine (O(6)BG), which enhanced the hematological toxicity of temozolomide METHODS: Temozolomide was administered orally, daily for 5 days starting at 28 mg/m(2) per day with escalations to 40, 55, 75...

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發表在:Cancer Chemother Pharmacol
Main Authors: Meany, Holly J., Warren, Katherine E., Fox, Elizabeth, Cole, Diane E., Aikin, Alberta A., Balis, Frank M.
格式: Artigo
語言:Inglês
出版: 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301000/
https://ncbi.nlm.nih.gov/pubmed/19430790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1015-8
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