Phase I Trial and Pharmacokinetic Study of Ixabepilone Administered Daily for 5 Days in Children and Adolescents With Refractory Solid Tumors

PURPOSE: The objectives of this phase I trial were to determine the maximum-tolerated dose (MTD), toxicity profile, dose-limiting toxicities (DLTs), pharmacokinetics, and preliminary response rate for ixabepilone, a microtubule-stabilizing agent, administered intravenously daily for 5 days in childr...

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Bibliographische Detailangaben
Hauptverfasser: Widemann, Brigitte C., Goodspeed, Wendy, Goodwin, Anne, Fojo, Tito, Balis, Frank M., Fox, Elizabeth
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2009
Schlagworte:
Original Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645861/
https://ncbi.nlm.nih.gov/pubmed/19075272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.17.6644
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