Development of an Opsonophagocytic Killing Assay Using HL-60 Cells for Detection of Functional Antibodies against Streptococcus pyogenes

The clinical development of group A streptococcal (GAS) vaccines will require the implementation of a standardized, high-throughput assay to measure the activity of functional opsonic antibodies in vaccine recipients. In the present study, we adapted and modified the HL-60-based protocol that was de...

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Bibliographic Details
Published in:mSphere
Main Authors: Salehi, Sanaz, Hohn, Claudia M., Penfound, Thomas A., Dale, James B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300688/
https://ncbi.nlm.nih.gov/pubmed/30567901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00617-18
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