General decapping activators target different subsets of inefficiently translated mRNAs

The Dcp1-Dcp2 decapping enzyme and the decapping activators Pat1, Dhh1, and Lsm1 regulate mRNA decapping, but their mechanistic integration is unknown. We analyzed the gene expression consequences of deleting PAT1, LSM1, or DHH1, or the DCP2 C-terminal domain, and found that: i) the Dcp2 C-terminal...

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Bibliographic Details
Published in:eLife
Main Authors: He, Feng, Celik, Alper, Wu, Chan, Jacobson, Allan
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Chromosomes and Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300357/
https://ncbi.nlm.nih.gov/pubmed/30520724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34409
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