Kappa Opioid Receptor Distribution and Function in Primary Afferents

Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newly developed KOR-cre knockin allele, viral tracing, single-cell RT-PCR, and ex vivo recordings, we show that KO...

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Udgivet i:Neuron
Main Authors: Snyder, Lindsey M., Chiang, Michael C., Loeza-Alcocer, Emanuel, Omori, Yu, Hachisuka, Junichi, Sheahan, Tayler D., Gale, Jenna R., Adelman, Peter C., Sypek, Elizabeth I., Fulton, Stephanie A., Friedman, Robert L., Wright, Margaret C., Duque, Melissa Giraldo, Lee, Yeon Sun, Hu, Zeyu, Huang, Huizhen, Cai, Xiaoyun, Meerschaert, Kimberly A., Nagarajan, Vidhya, Hirai, Toshiro, Scherrer, Gregory, Kaplan, Daniel H., Porreca, Frank, Davis, Brian M., Gold, Michael S., Koerber, H. Richard, Ross, Sarah E.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300132/
https://ncbi.nlm.nih.gov/pubmed/30236284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.08.044
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