Kappa Opioid Receptor Distribution and Function in Primary Afferents

Primary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newly developed KOR-cre knockin allele, viral tracing, single-cell RT-PCR, and ex vivo recordings, we show that KO...

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Pubblicato in:Neuron
Autori principali: Snyder, Lindsey M., Chiang, Michael C., Loeza-Alcocer, Emanuel, Omori, Yu, Hachisuka, Junichi, Sheahan, Tayler D., Gale, Jenna R., Adelman, Peter C., Sypek, Elizabeth I., Fulton, Stephanie A., Friedman, Robert L., Wright, Margaret C., Duque, Melissa Giraldo, Lee, Yeon Sun, Hu, Zeyu, Huang, Huizhen, Cai, Xiaoyun, Meerschaert, Kimberly A., Nagarajan, Vidhya, Hirai, Toshiro, Scherrer, Gregory, Kaplan, Daniel H., Porreca, Frank, Davis, Brian M., Gold, Michael S., Koerber, H. Richard, Ross, Sarah E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300132/
https://ncbi.nlm.nih.gov/pubmed/30236284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.08.044
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