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T cell cytolytic capacity is independent of initial stimulation strength

How cells respond to a myriad of stimuli with finite signaling machinery is central to immunology. In naive T cells, the inherent effect of ligand strength on activation pathways and endpoints remains controversial, confounded by environmental fluctuations and intercellular variability within popula...

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Bibliographic Details
Published in:Nat Immunol
Main Authors: Richard, Arianne C., Lun, Aaron T. L., Lau, Winnie W. Y., Göttgens, Berthold, Marioni, John C., Griffiths, Gillian M.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300116/
https://ncbi.nlm.nih.gov/pubmed/30013148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0160-9
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