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Design of Stapled Oxyntomodulin Analogs Containing Functionalized Biphenyl Cross-Linkers
A panel of three lipid-modified, functionalized biphenyl cross-linkers (fBph) were synthesized and subsequently employed in the preparation of the stapled oxyntomodulin (OXM) analogs. In a luciferase-based reporter assay, these stapled OXM analogs showed varying degree of potency in activating GLP-1...
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| Veröffentlicht in: | Tetrahedron |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6300064/ https://ncbi.nlm.nih.gov/pubmed/30581241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2018.11.060 |
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