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A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

BACKGROUND: The main purpose of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of toxicity. Existing methods developed for single-agent dose-finding assume that the dose-toxicity relation...

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Bibliografski detalji
Izdano u:BMC Med Res Methodol
Glavni autori: Tang, Niansheng, Wang, Songjian, Ye, Gen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299663/
https://ncbi.nlm.nih.gov/pubmed/30563454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-018-0604-9
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