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A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
BACKGROUND: The main purpose of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of toxicity. Existing methods developed for single-agent dose-finding assume that the dose-toxicity relation...
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| Publicado no: | BMC Med Res Methodol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6299663/ https://ncbi.nlm.nih.gov/pubmed/30563454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-018-0604-9 |
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