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A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
BACKGROUND: The main purpose of dose-finding studies in Phase I trial is to estimate maximum tolerated dose (MTD), which is the maximum test dose that can be assigned with an acceptable level of toxicity. Existing methods developed for single-agent dose-finding assume that the dose-toxicity relation...
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| 出版年: | BMC Med Res Methodol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6299663/ https://ncbi.nlm.nih.gov/pubmed/30563454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-018-0604-9 |
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