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Cyclical Treatment of Colorectal Tumor Spheroids Induces Resistance to MEK Inhibitors

Adaptive drug resistance is a major obstacle to successful treatment of colorectal cancers. Physiologic tumor models of drug resistance are crucial to understand mechanisms of treatment failure and improve therapy by developing new therapeutics and treatment strategies. Using our aqueous two-phase s...

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Publicado en:Transl Oncol
Main Authors: Shahi Thakuri, Pradip, Luker, Gary D., Tavana, Hossein
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press 2018
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299152/
https://ncbi.nlm.nih.gov/pubmed/30550927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.11.009
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