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Synergistic Inhibition of Kinase Pathways Overcomes Resistance of Colorectal Cancer Spheroids to Cyclic Targeted Therapies
[Image: see text] Cancer cells often adapt to single-agent treatments with chemotherapeutics. Activation of alternative survival pathways is a major mechanism of drug resistance. A potential approach to block this feedback signaling is using combination treatments of a pair of drugs, although toxici...
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| Publicado no: | ACS Pharmacol Transl Sci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2019
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7088992/ https://ncbi.nlm.nih.gov/pubmed/32259061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.9b00042 |
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