The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

Voltage-sensing phosphatases (VSP) contain a voltage sensor domain (VSD) similar to that of voltage-gated ion channels but lack a pore-gate domain. A VSD in a VSP regulates the cytoplasmic catalytic region (CCR). However, the mechanisms by which the VSD couples to the CCR remain elusive. Here we rep...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Kawanabe, Akira, Hashimoto, Masaki, Nishizawa, Manami, Nishizawa, Kazuhisa, Narita, Hirotaka, Yonezawa, Tomoko, Jinno, Yuka, Sakata, Souhei, Nakagawa, Atsushi, Okamura, Yasushi
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Assuntos:
Structural Biology and Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298786/
https://ncbi.nlm.nih.gov/pubmed/30484774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41653
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