Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients

Microarray technology fails in detecting point mutations present in a small fraction of cells from heterogeneous tissue samples or in plasma in a background of wild-type cell-free circulating tumor DNA (ctDNA). The aim of this study is to overcome the lack of sensitivity and specificity of current m...

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Publicado en:PLoS One
Autores principales: Damin, Francesco, Galbiati, Silvia, Soriani, Nadia, Burgio, Valentina, Ronzoni, Monica, Ferrari, Maurizio, Chiari, Marcella
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298683/
https://ncbi.nlm.nih.gov/pubmed/30562355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207876
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