iRGD-guided tumor penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer

Pancreatic cancer is one of the leading causes of cancer death, with 5-year survival of 8.5%. The lack of significant progress in improving therapy reflects our inability to overcome the desmoplastic stromal barrier in pancreatic ductal adenocarcinoma (PDAC) as well as a paucity of new approaches ta...

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Bibliografische gegevens
Gepubliceerd in:Mol Cancer Ther
Hoofdauteurs: Lo, Justin H., Hao, Liangliang, Muzumdar, Mandar D., Raghavan, Srivatsan, Kwon, Ester J., Pulver, Emilia M., Hsu, Felicia, Aguirre, Andrew J., Wolpin, Brian M., Fuchs, Charles S., Hahn, William C., Jacks, Tyler, Bhatia, Sangeeta N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298224/
https://ncbi.nlm.nih.gov/pubmed/30097486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-1090
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