MARCH3 attenuates IL-1β–triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI

The proinflammatory cytokine IL-1β plays critical roles in inflammatory and autoimmune diseases. IL-1β signaling is tightly regulated to avoid excessive inflammatory response. In this study, we identified the E3 ubiquitin ligase membrane-associated RING-CH-type finger 3 (MARCH3) as a critical negati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lin, Heng, Gao, Deng, Hu, Ming-Ming, Zhang, Man, Wu, Xiao-Xia, Feng, Lu, Xu, Wen-Hua, Yang, Qing, Zhong, Xuan, Wei, Jin, Xu, Zhi-Sheng, Zhang, Hong-Xia, Song, Ze-Min, Zhou, Qian, Ye, Wen, Liu, Ying, Li, Shu, Shu, Hong-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6298087/
https://ncbi.nlm.nih.gov/pubmed/30442668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806217115
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