JunB regulates homeostasis and suppressive functions of effector regulatory T cells

Foxp3-expressing CD4(+) regulatory T (Treg) cells need to differentiate into effector Treg (eTreg) cells to maintain immune homeostasis. T-cell receptor (TCR)-dependent induction of the transcription factor IRF4 is essential for eTreg differentiation, but how IRF4 activity is regulated in Treg cells...

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Publicat a:Nat Commun
Autors principals: Koizumi, Shin-ichi, Sasaki, Daiki, Hsieh, Tsung-Han, Taira, Naoyuki, Arakaki, Nana, Yamasaki, Shinichi, Wang, Ke, Sarkar, Shukla, Shirahata, Hiroki, Miyagi, Mio, Ishikawa, Hiroki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297218/
https://ncbi.nlm.nih.gov/pubmed/30559442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07735-4
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