Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway

Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly malignancies with <5% five-year survival rate due to late diagnosis, limited treatment options and chemoresistance. There is thus an urgent unmet clinical need to develop effective anticancer drugs to treat pancreatic cancer. Here,...

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Publicado en:Sci Rep
Autores principales: Wang, Xin, Wu, Xingye, Zhang, Zhonglin, Ma, Chao, Wu, Tingting, Tang, Shengli, Zeng, Zongyue, Huang, Shifeng, Gong, Cheng, Yuan, Chengfu, Zhang, Linghuan, Feng, Yixiao, Huang, Bo, Liu, Wei, Zhang, Bo, Shen, Yi, Luo, Wenping, Wang, Xi, Liu, Bo, Lei, Yan, Ye, Zhenyu, Zhao, Ling, Cao, Daigui, Yang, Lijuan, Chen, Xian, Haydon, Rex C., Luu, Hue H., Peng, Bing, Liu, Xubao, He, Tong-Chuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297164/
https://ncbi.nlm.nih.gov/pubmed/30559409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36214-5
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