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Variable population prevalence estimates of germline TP53 variants: a gnomAD-based analysis
Reports of variable cancer penetrance in Li-Fraumeni syndrome (LFS) have raised questions regarding the prevalence of pathogenic germline TP53 variants. We previously reported higher-than-expected population prevalence estimates in sequencing databases composed of individuals unselected for cancer h...
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| Izdano u: | Hum Mutat |
|---|---|
| Glavni autori: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6296902/ https://ncbi.nlm.nih.gov/pubmed/30352134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23673 |
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